{"id":171,"date":"2026-10-13T10:35:54","date_gmt":"2026-10-13T02:35:54","guid":{"rendered":"http:\/\/duanmu.9ykeji.com\/index.php\/products\/sedanling-en\/"},"modified":"2026-10-15T15:37:41","modified_gmt":"2026-10-15T07:37:41","slug":"sedanling-en","status":"publish","type":"product","link":"http:\/\/duanmu.9ykeji.com\/index.php\/en\/products\/sedanling-en\/","title":{"rendered":"SDL\uff08Sucrose Dilaurate + Sucrose Laurate\uff09"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Conventional whitening ingredients interrupt melanin formation pathways by acting on each node of melanogenesis. Sepiwhite MSH adopts a distinctive mechanism. Unlike traditional spot-fading principles, it inhibits HMGB1 protein to suppress melanocyte dendrite formation and block melanin transfer to keratinocytes. It restrains melanin formation at the source and reduces the formation of spots and acne marks<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Composition Information<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>Component Type<\/th><th>INCI<\/th><th>CAS<\/th><th>EC<\/th><\/tr><\/thead><tbody><tr><td>Components<\/td><td>SUCROSE DILAURATE<\/td><td>25915-57-5 <\/td><td>247-345-5 <\/td><\/tr><tr><td>Components<\/td><td>SUCROSE LAURATE<\/td><td>25339-99-5 \/ 37266-93-6<\/td><td>246-873-3 \/ 253-432-9<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Literature &amp; Patents<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Supported by published research papers in the *Journal of the European Academy of Dermatology and Venereology (JEADV)*.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Mechanism of Action<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">1. Inhibition of HMGB1 release: SDL reduces the release of cellular HMGB1 protein in a dose\u2011dependent manner.<br>2. Inhibition of melanocyte dendrite growth: The downregulation of HMGB1 suppresses the length and branching of melanocyte dendrites.<br>3. Blockade of pigment transport: The transfer of melanosomes to keratinocytes is blocked, reducing pigment deposition and spot formation.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Experimental Data<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">1. HMGB1 release inhibition test: The release of HMGB1 decreases with the increase of SDL concentration in a dose-dependent manner.<br>2. Human spot area test: For formulation with 1% SDL, significant reduction in spot area fraction is observed at week 4, week 6 and week 8 compared with control group.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Does not directly inhibit tyrosinase; targets HMGB1 protein, inhibits melanocyte dendrite formation and blocks melanosome transport to keratinocytes; the inhibitory effect is reversible with good cellular safety<\/p>\n","protected":false},"featured_media":422,"menu_order":0,"template":"","meta":[],"product_cat":[95],"product_tag":[],"class_list":["post-171","product","type-product","status-publish","has-post-thumbnail","hentry","product_cat-meibai-danban-en"],"_links":{"self":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product\/171","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/media\/422"}],"wp:attachment":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/media?parent=171"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=171"},{"taxonomy":"product_tag","embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=171"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}