{"id":174,"date":"2026-10-13T10:36:02","date_gmt":"2026-10-13T02:36:02","guid":{"rendered":"http:\/\/duanmu.9ykeji.com\/index.php\/products\/pyran-whitening-en\/"},"modified":"2026-10-15T15:37:42","modified_gmt":"2026-10-15T07:37:42","slug":"pyran-whitening-en","status":"publish","type":"product","link":"http:\/\/duanmu.9ykeji.com\/index.php\/en\/products\/pyran-whitening-en\/","title":{"rendered":"Pyran Brightening Agent"},"content":{"rendered":"\n

It is specially designed for skin brightening applications with no cytotoxicity, irritation or sensitization reactions. It delivers remarkable skin whitening benefits and fights photoaging<\/p>\n\n\n\n

Composition Information<\/h3>\n\n\n\n
INCI<\/th>CAS<\/th>EC<\/th><\/tr><\/thead>
DIMETHYLMETHOXY CHROMANOL<\/td>83923-51-7<\/td><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Mechanism of Action<\/h3>\n\n\n\n

1. Inhibit tyrosinase activity, block the conversion of tyrosine to dopa and dopaquinone, and reduce pigment biosynthesis.
2. Dual free radical scavenging: Eliminate reactive oxygen species (ROS) and reactive nitrogen species (RNS), relieve skin oxidative stress and mitigate damage induced by UV radiation and external pollutants.
3. Photoprotective effect: Reduce UV-induced damage to human epidermal keratinocytes and lower pigment deposition triggered by photodamage.<\/p>\n\n\n\n

Experimental Data<\/h3>\n\n\n\n

1. In vitro mushroom tyrosinase inhibition test (0.1 mM): Pyran brightening agent achieves 37% tyrosinase inhibition.
2. In vitro human tyrosinase inhibition test (0.1 mM): Pyran brightening agent achieves 43% tyrosinase inhibition.
3. In vitro melanin test on human melanocytes: Treatment with 0.1 mM pyran brightening agent for 5 days yields 45.87% pigment lightening improvement; 9-day treatment yields 61.2% pigment lightening improvement. The brightening effect is dose-dependent.
4. Keratinocyte photoprotection test: After pretreatment with pyran brightening agent, cell viability under UV irradiation is significantly improved. Cell proliferation capacity increases by 190.4% at 47 \u03bcg\/mL and 254.88% at 150 \u03bcg\/mL.
5. Human facial skin brightening test (0.1% inclusion, twice daily for 2 months, n=20): Significant improvement in skin luminance and brightening index is observed at day 30 and day 60 compared with blank control.
6. Human pigment spot test (0.5% inclusion): After 30 days of application, melasma appearance improves by 48% and freckle appearance improves by 47%. At day 60, melasma appearance improves by 72% and freckle appearance improves by 67%.<\/p>\n","protected":false},"excerpt":{"rendered":"

Lipophilic raw material; scavenges both oxygen free radicals (ROS) and nitrogen free radicals (RNS); excellent formulation stability; non-mutagenic, no cytotoxicity and no phototoxicity at the tested concentrations.<\/p>\n","protected":false},"featured_media":423,"menu_order":0,"template":"","meta":[],"product_cat":[95],"product_tag":[],"class_list":["post-174","product","type-product","status-publish","has-post-thumbnail","hentry","product_cat-meibai-danban-en"],"_links":{"self":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product\/174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/media\/423"}],"wp:attachment":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/media?parent=174"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=174"},{"taxonomy":"product_tag","embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}