{"id":200,"date":"2026-10-13T10:37:13","date_gmt":"2026-10-13T02:37:13","guid":{"rendered":"http:\/\/duanmu.9ykeji.com\/index.php\/products\/hongfuxiu-ds-pt\/"},"modified":"2026-10-15T15:37:44","modified_gmt":"2026-10-15T07:37:44","slug":"hongfuxiu-ds-pt","status":"publish","type":"product","link":"http:\/\/duanmu.9ykeji.com\/index.php\/pt\/products\/hongfuxiu-ds-pt\/","title":{"rendered":"Sulfato de dextrano s\u00f3dico (DS)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">O sulfato de dextrano de s\u00f3dio DS inibe eficazmente a ciclooxigenase COX-2, suprime a secre\u00e7\u00e3o de prostaglandina PGE2 e reduz o eritema fotossens\u00edvel. Exibe efeitos favor\u00e1veis na vermelhid\u00e3o e incha\u00e7o induzidos por v\u00e1rias les\u00f5es cut\u00e2neas qu\u00edmicas ou f\u00edsicas.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Informa\u00e7\u00f5es sobre a composi\u00e7\u00e3o<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>Tipo de componente<\/th><th>INCI<\/th><th>CAS<\/th><th>EC<\/th><\/tr><\/thead><tbody><tr><td>Componentes<\/td><td>SODIUM DEXTRAN SULFATE<\/td><td>9011-18-1 <\/td><td><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Mecanismo de a\u00e7\u00e3o<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">1. Calmante e via de al\u00edvio da vermelhid\u00e3o: inibir a atividade da ciclooxigenase COX\u2011 2, reduzir a produ\u00e7\u00e3o de prostaglandina PGE2, bloquear a rea\u00e7\u00e3o inflamat\u00f3ria em cascata, aliviar a inflama\u00e7\u00e3o da pele e mitigar o eritema fotossens\u00edvel induzido por UV.<br>2. DNA prote\u00e7\u00e3o &amp; anti-envelhecimento caminho: Upregulate GADD45\u0251 express\u00e3o para auxiliar na repara\u00e7\u00e3o de DNA danificado e combater o estresse celular; upregulate TP63 express\u00e3o para promover a prolifera\u00e7\u00e3o e migra\u00e7\u00e3o de c\u00e9lulas-tronco da pele, manter a integridade epid\u00e9rmica e retardar a senesc\u00eancia celular da pele.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Dados experimentais<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">1. Teste de inibi\u00e7\u00e3o da express\u00e3o g\u00eanica COX-2 (fibroblastos humanos NHDF): 0,1 mg\/mL produz inibi\u00e7\u00e3o de 45%; inibi\u00e7\u00e3o m\u00e1xima de 61% \u00e9 alcan\u00e7ada em 1 mg\/mL. O efeito aumenta com a dosagem.<br>2. Teste de inibi\u00e7\u00e3o da secre\u00e7\u00e3o PGE2 (queratin\u00f3citos humanos, estimula\u00e7\u00e3o pr\u00f3-inflamat\u00f3ria PMA): Na concentra\u00e7\u00e3o de amostra de 2 mg\/mL, a taxa de inibi\u00e7\u00e3o m\u00e1xima da secre\u00e7\u00e3o PGE2 atinge 82%.<br>3. teste fotot\u00f3xico humano in vivo do eritema (lo\u00e7\u00e3o de Hongfuxiu DS de 0,4%): Consegue a inibi\u00e7\u00e3o de 24% contra o eritema fotorresponsivo UV-induzido.<br>4. Teste de promo\u00e7\u00e3o da express\u00e3o g\u00eanica TP63 (c\u00e9lulas NHDF): 0,1 mg\/mL d\u00e1 115% upregulation; 1 mg\/mL d\u00e1 171% upregulation de uma maneira dependente da dose.<br>5. teste de promo\u00e7\u00e3o da express\u00e3o g\u00eanica GADD45\u03b1 (c\u00e9lulas NHDF): 0,1 mg\/mL d\u00e1 74% upregulation; 1 mg\/mL d\u00e1 157% upregulation de uma maneira dependente da dose.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pol\u00edmero de pequena mol\u00e9cula; sol\u00favel em \u00e1gua com boa absor\u00e7\u00e3o da pele; excelente toler\u00e2ncia da pele; certificado ECOCERT, classificado como ingrediente de baixa irrita\u00e7\u00e3o sob EWG VERIFIED; benef\u00edcios duplos: r\u00e1pida anti-inflama\u00e7\u00e3o e redu\u00e7\u00e3o de vermelhid\u00e3o e abrangente anti-envelhecimento<\/p>\n","protected":false},"featured_media":401,"menu_order":0,"template":"","meta":[],"product_cat":[112],"product_tag":[],"class_list":["post-200","product","type-product","status-publish","has-post-thumbnail","hentry","product_cat-kangyan-shumin-pt"],"_links":{"self":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product\/200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/media\/401"}],"wp:attachment":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/media?parent=200"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=200"},{"taxonomy":"product_tag","embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}