{"id":234,"date":"2026-10-13T10:38:41","date_gmt":"2026-10-13T02:38:41","guid":{"rendered":"http:\/\/duanmu.9ykeji.com\/index.php\/products\/vesicle-azelaic-acid-en\/"},"modified":"2026-10-15T15:37:48","modified_gmt":"2026-10-15T07:37:48","slug":"vesicle-azelaic-acid-en","status":"publish","type":"product","link":"http:\/\/duanmu.9ykeji.com\/index.php\/en\/products\/vesicle-azelaic-acid-en\/","title":{"rendered":"Vesicle Controlled Azelaic Acid"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Vesicle-Controlled Azelaic Acid offers multiple benefits including anti-inflammation, antimicrobial activity, whitening and pigment-lightening, widely used in skincare formulations for skin tone improvement. It adopts vesicle controlled-release technology to realize precise release, delivering high efficacy with minimal irritation. The vesicle controlled-release system forms stable, ordered and functional microspherical vesicle structures through intermolecular non-covalent interactions such as hydrogen bonding, electrostatic forces and hydrophobic effects<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Composition Information<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>Component Type<\/th><th>INCI<\/th><th>CAS<\/th><th>EC<\/th><\/tr><\/thead><tbody><tr><td>Components<\/td><td>AZELAIC ACID<\/td><td>123-99-9<\/td><td>204-669-1 <\/td><\/tr><tr><td>Components<\/td><td>OLEIC\/LINOLEIC\/LINOLENIC POLYGLYCERIDES<\/td><td><\/td><td><\/td><\/tr><tr><td>Components<\/td><td>STEARAMIDOPROPYL DIMETHYLAMINE<\/td><td>7651-02-7<\/td><td>231-609-1<\/td><\/tr><tr><td>Components<\/td><td>PHOSPHATIDYLCHOLINE<\/td><td>8002-43-5<\/td><td>232-307-2<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Mechanism of Action<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">1. Vesicle-targeted sustained-release transdermal pathway: Nanovesicles act on stratum corneum, loosen keratinocytes, alter phospholipid polarity of keratinocyte membrane and increase membrane fluidity. Azelaic acid is delivered into skin and released in a controlled, slow manner to reduce irritation risk caused by high local concentration.<br>2. Sebum regulation pathway: Inhibit 5\u03b1-reductase activity, reduce conversion of testosterone into DHT (dihydrotestosterone), restrain excessive sebum secretion of sebaceous glands, improve oily skin and mitigate root triggers of pore clogging.<br>3. Skin microbiome balancing pathway: Inhibit proliferation of *Cutibacterium acnes*, *Staphylococcus aureus*, *Pseudomonas aeruginosa* and *Escherichia coli*, reduce harmful microorganisms in hair follicles and improve inflammatory skin bumps.<br>4. Soothing &amp; redness-relieving pathway: Downregulate TLR4 protein expression, suppress NF\u2011\u03baB inflammatory signaling pathway, reduce release of inflammatory mediators, relieve blemish-induced skin redness and improve PIE (post-inflammatory erythema).<br>5. Pigment regulating pathway: Act on melanocytes, interfere with pigment synthesis and transport, improve PIH (post-inflammatory hyperpigmentation) and fade dark blemish marks.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Experimental Data<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">1. 5\u03b1-reductase inhibition test: 3% Vesicle Smart-Controlled Azelaic Acid achieves 95% inhibition of 5\u03b1-reductase.<br>2. Bacteriostatic test: It exhibits inhibitory effects against *Cutibacterium acnes*, *Staphylococcus aureus*, *Pseudomonas aeruginosa* and *Escherichia coli*, with the most prominent activity toward *Cutibacterium acnes*.<br>3. Cellular anti-inflammation test: 62.50 \u03bcg\/mL sample significantly reduces TLR4 protein expression in HaCaT cells induced by heat-inactivated *Cutibacterium acnes*, with an inhibition rate of 69%.<br>4. Skin lesion observation: It gradually improves the appearance of PIE post-inflammatory erythema and PIH post-inflammatory hyperpigmentation. Redness and pigment deposition are alleviated progressively with prolonged application.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vesicle-encapsulated sustained-release azelaic acid raw material; multiple benefits: oil control, bacteriostasis, anti-inflammation, anti-acne and improvement of post-inflammatory hyperpigmentation; retains azelaic acid efficacy while enhancing water solubility and formulation stability, lowering the risk of skin irritation; suitable for oily, acne-prone sensitive skin<\/p>\n","protected":false},"featured_media":413,"menu_order":0,"template":"","meta":[],"product_cat":[125],"product_tag":[],"class_list":["post-234","product","type-product","status-publish","has-post-thumbnail","hentry","product_cat-kongyou-qudou-en"],"_links":{"self":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product\/234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/media\/413"}],"wp:attachment":[{"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/media?parent=234"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=234"},{"taxonomy":"product_tag","embeddable":true,"href":"http:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}