{"id":243,"date":"2026-10-13T10:39:05","date_gmt":"2026-10-13T02:39:05","guid":{"rendered":"http:\/\/duanmu.9ykeji.com\/index.php\/products\/penetration-enhancer-dmi-en\/"},"modified":"2026-10-15T15:37:39","modified_gmt":"2026-10-15T07:37:39","slug":"penetration-enhancer-dmi-en","status":"publish","type":"product","link":"https:\/\/duanmu.9ykeji.com\/index.php\/en\/products\/penetration-enhancer-dmi-en\/","title":{"rendered":"Penetration Enhancer DMI (Dimethyl Isosorbide)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">DMI can significantly boost the penetration of active ingredients, enabling targeted permeation through the stratum corneum. As a new-generation safe and irritation-free penetration enhancer, it features excellent amphiphilic solubility in both oil and water, making it easier to incorporate into formulations. Clinical trials demonstrate its permeation-promoting effect is 3 times that of azone, while its safety profile is 370 times higher than azone.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Composition Information<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>INCI<\/th><th>CAS<\/th><th>EC<\/th><\/tr><\/thead><tbody><tr><td>DIMETHYL ISOSORBIDE<\/td><td>5306-85-4<\/td><td>226-159-8<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Literature &amp; Patents<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The relevant research paper *Study on the Application of Novel Penetration Enhancer DMI in Cosmetics* was published in *Chemical Enterprise Management*, Issue 29, 2024, and can be retrieved on CNKI.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Mechanism of Action<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">1. Dissolve free fatty acids in the stratum corneum of skin and improve the penetration capacity across skin membrane.<br>2. Act as a solvent to dissolve active ingredients and carry active components into skin.<br>3. Enhance the delivery and penetration performance of other ingredients in the formula.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Experimental Data<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">1. Benzoyl peroxide (BPO) test:<br>DMI can reduce the crystal size of BPO and inhibit crystal agglomeration to prevent skin scratch damage by particles. Patch test combined with laser Doppler perfusion imaging shows that 3% DMI significantly mitigates skin irritation induced by BPO.<br>2. Fluorescence penetration test on skin tissue sections (Guangzhou Institute of Medical Devices):<br>Compared with other common penetration enhancers at the same concentration, DMI enables marker penetration into the dermis with partial diffusion into subcutaneous tissue, demonstrating excellent penetration depth.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Low volatility, low toxicity, high boiling point with excellent safety performance<\/p>\n","protected":false},"featured_media":384,"menu_order":0,"template":"","meta":[],"product_cat":[135],"product_tag":[],"class_list":["post-243","product","type-product","status-publish","has-post-thumbnail","hentry","product_cat-qita-en"],"_links":{"self":[{"href":"https:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product\/243","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/media\/384"}],"wp:attachment":[{"href":"https:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/media?parent=243"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=243"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/duanmu.9ykeji.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=243"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}