EPS Cordyceps Polysaccharide

We screened robust wild Cordyceps strains and applied gene editing technology to boost the yield and bioactivity of its polysaccharides. In addition to retaining polysaccharides’ benefits for immunity enhancement, cell repair and skin strengthening, it contains mucinous polysaccharides which greatly promote the production and activity of elastin in skin, thereby improving skin elasticity and firmness, refining pores and lifting tissue to maintain a youthful appearance.

Composition Information

Mechanism of Action

1. Matrix-promoting anti-aging pathway: Modulate TGF‑β signaling pathway to boost type Ⅰ procollagen production; increase the contents of elastin, ceramide and glycosaminoglycan, strengthen dermal-epidermal junction and relieve skin laxity and enlarged pores.
2. Soothing pathway: Inhibit the activation of NF‑κB signaling pathway, downregulate the release of inflammatory mediators including IL‑6, IL‑8, TNF‑α, NO and PGE2 to mitigate skin inflammatory response.
3. Antioxidant pathway: Activate Nrf2 antioxidant pathway, upregulate HO‑1 and NQO‑1 expression, scavenge free radicals and reduce oxidative stress damage.
4. Photoprotective & repairing pathway: Inhibit MMP‑1 activity to reduce UV-induced collagen degradation; improve the state of UV-damaged cells and alleviate UV-triggered erythema injury.

Experimental Data

1. Extracellular matrix proliferation test: At concentrations of 0.1%, 1% and 2% EPS Cordyceps Polysaccharide, the ECM proliferation effect gradually improves with higher concentration and longer treatment time within 24‑72 h, outperforming commercial control.
2. Dermo-epidermal junction test: 5% EPS Cordyceps Polysaccharide enhances the strength of skin junction layer.
3. Stratum corneum moisture content test: Lotion with 2% EPS Cordyceps Polysaccharide increases stratum corneum water content.
4. MMP‑1 activity inhibition test: EPS Cordyceps Polysaccharide reduces MMP‑1 enzymatic activity and mitigates matrix degradation.
5. UV cell repair test: EPS Cordyceps Polysaccharide repairs skin cell damage induced by UV stimulation and improves cellular health.
6. Human skin elasticity test: Skin elasticity rises with increasing concentration of EPS Cordyceps Polysaccharide. 2% addition noticeably improves skin firmness; test subjects aged 40‑55 years old.
7. Human UV erythema test (cream with 1% EPS Cordyceps Polysaccharide): It reduces skin erythema value after UV irradiation and alleviates photodamage-related erythema.