Sodium Dextran Sulfate（DS）

Sodium Dextran Sulfate DS effectively inhibits cyclooxygenase COX-2, suppresses the secretion of prostaglandin PGE2 and reduces photosensitive erythema. It exhibits favorable effects on redness and swelling induced by various chemical or physical skin lesions.

Composition Information

Mechanism of Action

1. Soothing & redness-relieving pathway: Inhibit COX‑2 cyclooxygenase activity, reduce prostaglandin PGE2 production, block inflammatory cascade reaction, relieve skin inflammation and mitigate UV-induced photosensitive erythema.
2. DNA protection & anti-aging pathway: Upregulate GADD45ɑ expression to assist in repairing damaged DNA and counter cellular stress; upregulate TP63 expression to promote proliferation and migration of skin stem cells, maintain epidermal integrity and slow down skin cell senescence.

Experimental Data

1. COX‑2 gene expression inhibition test (NHDF human fibroblasts): 0.1 mg/mL yields 45% inhibition; maximum inhibition of 61% is achieved at 1 mg/mL. The effect increases with dosage.
2. PGE2 secretion inhibition test (human keratinocytes, PMA pro-inflammatory stimulation): At sample concentration of 2 mg/mL, the maximum inhibition rate of PGE2 secretion reaches 82%.
3. Human phototoxic erythema in-vivo test (0.4% Hongfuxiu DS lotion): It achieves 24% inhibition against UV-induced photoresponsive erythema.
4. TP63 gene expression promotion test (NHDF cells): 0.1 mg/mL gives 115% upregulation; 1 mg/mL gives 171% upregulation in a dose-dependent manner.
5. GADD45α gene expression promotion test (NHDF cells): 0.1 mg/mL gives 74% upregulation; 1 mg/mL gives 157% upregulation in a dose-dependent manner.