SkinHeal Silane

Silanediol salicylate is based on salicylic acid, a classic skincare ingredient. Through sophisticated organosilicon structural modification, it achieves an optimal balance between efficacy and mildness. It fully inherits the core advantage of salicylic acid for soothing and anti-inflammation, and overcomes the drawbacks of conventional salicylic acid: high irritation and poor stability.

Composition Information

Mechanism of Action

1. Soothing & anti-sensitivity pathway: Inhibit the activation of NF‑κB signaling pathway; downregulate inflammatory factors IL‑6, TNF‑α and IL‑1β, suppress the expression of iNOS and COX‑2, reduce NO production, relieve skin inflammatory response and alleviate redness and burning sensation.
2. Dermal repair pathway: Reactive silicon participates in skin structure construction, promotes fibroblast proliferation, boosts synthesis of type Ⅰ collagen and elastin, optimizes the arrangement of dermal collagen fibers and strengthens skin structure.
3. Photoprotective pathway: Precondition epidermal cells to mitigate UVB-induced cell damage and reduce photodamage.

Experimental Data

1. Anti-inflammation test on RAW264.7 cells (15 μg/mL SkinHeal Silane): IL‑6 inhibition 75%, TNF‑α inhibition 46.7%, IL‑1β inhibition 92.9%; NO production inhibition 35.7%; NF‑κB protein inhibition 98.5%.
2. Fibroblast proliferation test (2% SkinHeal Silane): It promotes fibroblast proliferation with a promotion rate of 42%.
3. Human dermal explant test (2% SkinHeal Silane): Type Ⅰ collagen fibers become more uniformly and densely arranged, and elastin content increases.
4. UVB photodamage protection test: Pre-treatment with 2% SkinHeal Silane protects epidermal structure and alleviates cell damage induced by UVB irradiation.
5. Human redness test (2% SkinHeal Silane repair cream): Redness improvement is observed at 24 h, continuous relief at 36 h, and obvious redness repair after 7 days.